Significant Shareholders

Shares in issue: 176.0m 10p Ordinary Shares in Issue, as at Last Close.

The percentage of shares not in public hands is 26.7% as of 14th November 2007.

The number of registered shareholders is 817 as of 31st August 2007.

Significant Shareholders Information
Shareholder Name (* - Executive/Director)Amount% Holding
Elder Pharmaceuticals FZCO37,101,78621.1
Rathbone Investment Management14,723,0848.4
Kaupthing Singer & Friedlander 9,647,8885.5
Stirling S L Mrs8,730,0025.0
Stirling J K Esq7,230,0024.1
Rensburg Sheppards Investment Management 6,800,0003.9
Artemis Investment Management6,450,0003.7
AXA Framlington Investment Management5,667,0233.2
Director Shareholdings
Director NameAmount% Holding
Gulam Kaderbhoy Noon4,112,1342.34
Anthony Bruton Good3,952,3802.25
Ronald James Stagg1,000,0000.57
James Stewart McEuen102,5000.06
Michael Hjelm Toxvaerd100,0010.06
Robin David Hilton25,0000.01

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Financial information provided by Hemscott Group Limited.